Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 7/20 | 0.74 |
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.74 |
| ▸ | OPRK1 known ✓ | P41145 | 4/20 | 0.74 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL27095402 | 0.98 | OPRD1 (0.71) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3476700 | 0.93 | OPRM1 (0.83) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL11057867 | 0.92 | OPRM1 (0.63) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Morphine SCHEMBL6266399 | 0.92 | OPRM1 (0.71) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3476298 | 0.90 | OPRM1 (0.78) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL6266395 | 0.90 | OPRD1 (0.67) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL2523531 | 0.90 | OPRD1 (0.60) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Aspirin SCHEMBL5482242 | 0.89 | OPRM1 (0.64) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3476555 | 0.89 | OPRD1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL6269822 | 0.89 | OPRM1 (0.75) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005086960-A2 | NARCOTIC-NSAID ION PAIRS | AAIPHARMA, INC. (US) | 2005-09-22 | — | — | WO | claimed |
| US-20050203115-A1 | Narcotic-NSAID ion pairs | WELLS FARGO BANK, N.A. | 2005-09-15 | — | — | US | claimed |
| US-20220226368-A1 | ESSENTIALLY SODIUM-FREE EFFERVESCENT SOLID PHARMACEUTICAL COMPOSITIONS | INTAS PHARMACEUTICALS LIMTED (IN) | 2022-07-21 | — | — | US | disclosed |
| WO-2021064636-A1 | ESSENTIALLY SODIUM-FREE EFFERVESCENT SOLID PHARMACEUTICAL COMPOSITIONS | INTAS PHARMACEUTICALS LTD. (IN) | 2021-04-08 | — | — | WO | disclosed |
| CN-103191136-A | Compound preparation containing aspirin and ilaprazole sodium and preparation method thereof | LIVZON GROUP LIVZON PHARMACEUTICAL PLANT | 2013-07-10 | — | — | CN | disclosed |
| CN-103191137-A | Compound preparation containing aspirin and proton pump inhibitor and preparation method thereof | LIVZON GROUP LIVZON PHARMACEUTICAL PLANT | 2013-07-10 | — | — | CN | disclosed |
| US-8271297-B2 | Automated order entry system and method | CERNER INNOVATION, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| CN-102225202-A | Compound preparation containing aspirin and proton pump inhibitor | UNIV SHANDONG | 2011-10-26 | — | — | CN | disclosed |
| US-7970621-B2 | Automated order entry system and method | CERNER INNOVATION, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-20110099029-A1 | AUTOMATED ORDER ENTRY SYSTEM AND METHOD | CERNER INNOVATION, INC. (US) | 2011-04-28 | — | — | US | disclosed |
| CN-100594904-C | Hydrochloride epinastine dispersing tablets and their production | WENJING ZHANG | 2010-03-24 | — | — | CN | disclosed |
| WO-2005086960-A2 | NARCOTIC-NSAID ION PAIRS | AAIPHARMA, INC. (US) | 2005-09-22 | — | — | WO | disclosed |
| US-20050203115-A1 | Narcotic-NSAID ion pairs | WELLS FARGO BANK, N.A. | 2005-09-15 | — | — | US | disclosed |
| US-20050147673-A1 | Directly compressible sustained release formulation containing microcrystalline cellulose | J. RETTENMAIER & SOEHNE GMBH + CO. KG (DE) | 2005-07-07 | — | — | US | disclosed |
| CN-1565448-A | Nitrendipine dispersion tablet and method for making same | HEBEI SAIKE PHARMACEUTICAL CO (CN) | 2005-01-19 | — | — | CN | disclosed |
| US-5869498-A | ADMINISTERING A COMBINATION OF OXYCODONE, NAPROXEN AND A NONTOXIC N-METHYL-D-ASPARATATE (NMDA) RECEPTOR ANTAGONIST SUCH AS DEXTRORPHAN OR DEXTROMETHORPHAN | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-02-09 | — | — | US | disclosed |
| US-5863922-A | AN ANALGESICS MIXTURE COMPRISING ACETAMINOPHEN, SEDATIVE BUTALBITAL AND A N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST SELECTED FROM DEXTRORPHAN, DEXTROMETHORPHAN | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-01-26 | — | — | US | disclosed |
| US-5840731-A | COMPOSITION COMPRISING OPIOID ANALGESIC, ACETAMINOPHEN, NONTOXIC N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1998-11-24 | — | — | US | disclosed |
| EP-0845989-A2 | PAIN-ALLEVIATING DRUG COMPOSITION AND METHOD FOR ALLEVIATING PAIN | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1997004780-A2 | PAIN-ALLEVIATING DRUG COMPOSITION AND METHOD FOR ALLEVIATING PAIN | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1997-02-13 | — | — | WO | disclosed |