Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.75 |
| ▸ | OPRD1 known ✓ | P41143 | 7/20 | 0.75 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.75 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.75 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.75 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.75 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL3476700 | 0.92 | OPRM1 (0.83) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3476298 | 0.91 | OPRM1 (0.78) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Morphine SCHEMBL6266392 | 0.91 | OPRD1 (0.75) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Codeine SCHEMBL3476555 | 0.90 | OPRD1 (0.91) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1642447 | 0.89 | OPRD1 (0.74) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL8769546 | 0.88 | OPRD1 (0.75) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL8418755 | 0.87 | OPRM1 (0.83) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL16922140 | 0.87 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL12638890 | 0.87 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL21077535 | 0.87 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005086960-A2 | NARCOTIC-NSAID ION PAIRS | AAIPHARMA, INC. (US) | 2005-09-22 | — | — | WO | claimed |
| US-20050203115-A1 | Narcotic-NSAID ion pairs | WELLS FARGO BANK, N.A. | 2005-09-15 | — | — | US | claimed |
| WO-2005086960-A2 | NARCOTIC-NSAID ION PAIRS | AAIPHARMA, INC. (US) | 2005-09-22 | — | — | WO | disclosed |
| US-20050203115-A1 | Narcotic-NSAID ion pairs | WELLS FARGO BANK, N.A. | 2005-09-15 | — | — | US | disclosed |