Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | AKT2 | P31751 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.54 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16426792 | 1.00 | IKBKB (0.54) | IKBKBRAF1RPS6KB1MAPK1AKT1 | |
| SCHEMBL16427343 | 0.77 | KDR (0.49) | IKBKBKDRNFE2L2 | |
| SCHEMBL16427344 | 0.77 | KDR (0.49) | IKBKBKDRNFE2L2 | |
| SCHEMBL28129799 | 0.75 | MAOB (0.43) | MAPK1ALDH1A1LMNAHTTMAPT | |
| SCHEMBL30603084 | 0.74 | MAPT (0.53) | RPS6KB1AKT1KDRMAPK14NPC1 | |
| SCHEMBL28620148 | 0.72 | KDM4E (0.54) | KDRMAP2K1NPC1ACHEALDH1A1 | |
| SCHEMBL3692774 | 0.71 | NOS2 (0.41) | IKBKBRAF1RPS6KB1MAPK1AKT1 | |
| SCHEMBL30785015 | 0.71 | NOS2 (0.41) | IKBKBRAF1RPS6KB1MAPK1AKT1 | |
| SCHEMBL3692772 | 0.71 | NOS2 (0.41) | IKBKBRAF1RPS6KB1MAPK1AKT1 | |
| SCHEMBL15291319 | 0.71 | JAK2 (0.39) | IKBKBRAF1RPS6KB1MAPK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038543-A1 | ANTI-GLYCATION PROPERTIES OF OXINDOLE DERIVATIVES | CHOUDHARY MUHAMMAD IQBAL (PK) | 2015-02-05 | — | — | US | disclosed |