Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168302 | 0.86 | NPC1 (0.56) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL168201 | 0.84 | KMT2A (0.50) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL167753 | 0.79 | NPC1 (0.47) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL176297 | 0.74 | NPC1 (0.57) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL168920 | 0.74 | NPC1 (0.46) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL176089 | 0.73 | NPC1 (0.56) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL167649 | 0.73 | NPC1 (0.45) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL31226974 | 0.73 | CA12 (0.56) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL168121 | 0.72 | NPC1 (0.73) | NPC1RAB9ALMNAKDM4EKMT2A | |
| SCHEMBL167729 | 0.72 | KMT2A (0.55) | NPC1RAB9ALMNAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |