Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167729 | 0.87 | KMT2A (0.55) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL176199 | 0.86 | KMT2A (0.50) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL13860921 | 0.85 | KMT2A (0.67) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL168302 | 0.85 | NPC1 (0.56) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL167753 | 0.85 | NPC1 (0.47) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL164282 | 0.84 | NPC1 (0.47) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL167000 | 0.81 | NPC1 (0.73) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL31226974 | 0.79 | CA12 (0.56) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL6467527 | 0.74 | KDM4E (0.47) | KMT2ANPC1RAB9AMEN1LMNA | |
| SCHEMBL6499913 | 0.74 | LRRK2 (0.46) | KMT2ANPC1RAB9AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |