Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DDX3X | O00571 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169117 | 0.88 | KMT2A (0.51) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL167504 | 0.87 | NPC1 (0.47) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL168201 | 0.85 | KMT2A (0.50) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL168302 | 0.82 | NPC1 (0.56) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL164282 | 0.79 | NPC1 (0.47) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL31226974 | 0.76 | CA12 (0.56) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL167729 | 0.72 | KMT2A (0.55) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL6467527 | 0.71 | KDM4E (0.47) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL176199 | 0.71 | KMT2A (0.50) | NPC1RAB9ALMNAKDM4EL3MBTL1 | |
| SCHEMBL13860921 | 0.71 | KMT2A (0.67) | NPC1RAB9ALMNAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |