Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176297 | 0.88 | NPC1 (0.57) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL176089 | 0.87 | NPC1 (0.56) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL164282 | 0.86 | NPC1 (0.47) | NPC1RAB9ALMNAKDM4EKMT2A | |
| SCHEMBL168121 | 0.86 | NPC1 (0.73) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL168201 | 0.85 | KMT2A (0.50) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL164749 | 0.82 | AURKA (0.51) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL167753 | 0.82 | NPC1 (0.47) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL30297750 | 0.81 | AURKA (0.51) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL168443 | 0.77 | AURKA (0.41) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL30367344 | 0.76 | NPC1 (0.65) | NPC1RAB9ALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |