Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | CASP1 | P29466 | 2/20 | 0.64 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.64 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16435362 | 0.89 | HCRTR2 (0.63) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL14907102 | 0.80 | HCRTR2 (0.82) | HCRTR2HCRTR1 | |
| SCHEMBL14907184 | 0.71 | HCRTR2 (0.81) | HCRTR2HCRTR1 | |
| SCHEMBL4777731 | 0.68 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDGAASMN1; SMN2 | |
| SCHEMBL10250655 | 0.68 | KDM4E (0.54) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL2777497 | 0.68 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL14907104 | 0.67 | HCRTR2 (0.88) | HCRTR2HCRTR1 | |
| SCHEMBL2777247 | 0.66 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL8394530 | 0.66 | JUN (0.52) | ALDH1A1KDM4EHPGDGAACASP1 | |
| SCHEMBL3720931 | 0.66 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDGAACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242995-B2 | Isoxazolopyridine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-9242995-B2 | Isoxazolopyridine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150038502-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-02-05 | — | — | US | disclosed |
| US-20150038502-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038502-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY5R | ALDH1A1 2470/4885KDM4E 1493/4885HPGD 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.