Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.42 |
| ▸ | PDE2A | O00408 | 12/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644385 | 0.92 | MAOB (0.43) | HPGDSPDE2AMAOBDDR2 | |
| SCHEMBL1645206 | 0.91 | HPGDS (0.43) | HPGDSPDE2AMAOB | |
| SCHEMBL1285744 | 0.87 | TRPV1 (0.49) | — | |
| SCHEMBL14377430 | 0.86 | HPGDS (0.44) | HPGDSPDE2AMAOBDDR2 | |
| SCHEMBL1645337 | 0.85 | PDE2A (0.42) | HPGDSPDE2AMAOB | |
| SCHEMBL1644700 | 0.83 | HPGDS (0.42) | HPGDSPDE2A | |
| SCHEMBL1645222 | 0.83 | HPGDS (0.43) | HPGDSPDE2A | |
| SCHEMBL1285302 | 0.80 | HPGDS (0.43) | HPGDSPDE2AMAOB | |
| SCHEMBL1285590 | 0.80 | DDR2 (0.42) | HPGDSPDE2AMAOBDDR2 | |
| SCHEMBL1644611 | 0.80 | HPGDS (0.46) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | HPGDS 427/4885PDE2A 1116/4885MAOB 3327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.