Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.39 |
| ▸ | KDM6B | O15054 | 5/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 2/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.31 |
| ▸ | CCNC | P24863 | 3/20 | 0.31 |
| ▸ | CDK8 | P49336 | 3/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | KDM4A | O75164 | 2/20 | 0.30 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27791683 | 0.66 | KDM4C (0.37) | KDM4CKDM6BHCAR2HCAR3L3MBTL1 | |
| SCHEMBL30763949 | 0.60 | CCNC (0.35) | KDM4CKDM6BHCAR2HCAR3CCNC | |
| SCHEMBL30440354 | 0.60 | KDM4C (0.36) | KDM4CKDM6BHCAR2HCAR3L3MBTL1 | |
| SCHEMBL8366169 | 0.60 | KDM4C (0.36) | KDM4CKDM6BHCAR2HCAR3L3MBTL1 | |
| SCHEMBL30539758 | 0.59 | SIRT3 (0.38) | KDM4CKDM6BCCNCCDK8HASPIN | |
| SCHEMBL5090090 | 0.59 | KDM4C (0.31) | KDM4CKDM6BKDM4EALDH1A1MAPT | |
| SCHEMBL15295165 | 0.56 | KDM4C (1.00) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL115648 | 0.56 | KDM4C (0.56) | KDM4CKDM6BL3MBTL1KDM4EKDM4A | |
| SCHEMBL30465694 | 0.56 | KDM4C (0.51) | KDM4CKDM6BL3MBTL1KDM4EKDM4A | |
| SCHEMBL30100781 | 0.56 | KDM4C (0.56) | KDM4CKDM6BL3MBTL1KDM4EKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688675-B2 | 1,7-naphthyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-06-27 | — | — | US | disclosed |
| EP-3027597-B1 | 1,7-NAPHTHYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-05-03 | — | — | EP | disclosed |
| EP-3027597-A1 | 1,7-NAPHTHYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-06-08 | — | — | EP | disclosed |
| US-20160137643-A1 | 1,7-NAPHTHYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-05-19 | — | — | US | disclosed |
| WO-2015014768-A1 | 1,7-NAPHTHYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137643-A1 | 1,7-NAPHTHYRIDINE DERIVATIVES | DRD2, DRD4, DRD1 | KDM4C 4556/4885KDM6B 4808/4885HCAR2 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.