Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.44 |
| ▸ | CDK2 | P24941 | 10/20 | 0.44 |
| ▸ | CDK4 | P11802 | 7/20 | 0.44 |
| ▸ | CCND1 | P24385 | 7/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285218 | 0.91 | CSNK2A1 (0.54) | KMT2ASIRT5TLR7CSNK2A2CSNK2B | |
| SCHEMBL1688412 | 0.89 | KMT2A (0.48) | KMT2ASIRT5TLR7CSNK2A2CSNK2B | |
| SCHEMBL1645135 | 0.82 | MAPT (0.58) | KMT2ACSNK2A1MEN1FLT3CYP1A2 | |
| SCHEMBL1644149 | 0.74 | PPARG (0.36) | KMT2ASIRT5TLR7CSNK2A2CSNK2B | |
| SCHEMBL1284831 | 0.73 | MAPT (0.58) | KMT2ACSNK2A1MEN1FLT3CYP1A2 | |
| SCHEMBL13975842 | 0.73 | TLR7 (0.56) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL1688376 | 0.72 | MAPT (0.57) | KMT2AMEN1FLT3TSHR | |
| SCHEMBL17254446 | 0.71 | ALDH1A1 (0.46) | KMT2AMEN1CYP1A2 | |
| SCHEMBL11108977 | 0.68 | KMT2A (0.53) | KMT2AMEN1 | |
| SCHEMBL1644300 | 0.68 | TLR7 (0.57) | KMT2ATLR7CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | KMT2A 4280/4885SIRT5 1568/4885TLR7 1332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.