SCHEMBL16440282

SCHEMBL16440282

CCOc1ccc(Oc2ccc(F)cc2F)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 1/20 0.59
HSPB1 P04792 1/20 0.54
MAPT P10636 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
LMNA P02545 1/20 0.50
ATM Q13315 1/20 0.50
NQO1 P15559 1/20 0.48
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C19 P33261 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
SCN8A Q9UQD0 1/20 0.47
SCN10A Q9Y5Y9 1/20 0.47
LTA4H P09960 2/20 0.47
SLC6A4 P31645 2/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A3 Q01959 1/20 0.46
TRPA1 O75762 4/20 0.46
AR P10275 1/20 0.44
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18570814 0.85 CACNA1C (0.54) CACNA1CMAPTL3MBTL1LMNAATM
SCHEMBL12967549 0.83 HSPB1 (0.54) CACNA1CHSPB1SLC6A4SLC6A2SLC6A3
SCHEMBL1547577 0.81 L3MBTL1 (0.53) CACNA1CL3MBTL1CYP1A2CYP2D6CYP2C19
SCHEMBL8754808 0.81 AR (0.49) CACNA1CMAPTL3MBTL1LMNAATM
SCHEMBL9339651 0.80 HSPB1 (0.58) HSPB1L3MBTL1LMNACYP1A2CYP2C19
SCHEMBL8298015 0.80 HSPB1 (0.58) HSPB1LMNASLC6A4SLC6A2SLC6A3
SCHEMBL18570379 0.80 CACNA1C (0.50) CACNA1CMAPTL3MBTL1LMNAATM
SCHEMBL22874669 0.79 LTA4H (0.65) CACNA1CL3MBTL1NQO1CYP1A2CYP2D6
SCHEMBL1749720 0.77 MAPT (0.51) HSPB1MAPTL3MBTL1LMNACYP1A2
Hydrochloric Acid SCHEMBL7027262 0.77 CACNA1C (0.80) CACNA1CMAPTL3MBTL1LMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015017502-A1 PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF MERCK PATENT GMBH (DE) 2015-02-05 WO disclosed