Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.36 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285253 | 0.94 | TRPV1 (0.40) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285686 | 0.94 | TRPV1 (0.40) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285873 | 0.93 | TRPV1 (0.40) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1286035 | 0.92 | MAPK1 (0.46) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285193 | 0.92 | TRPV1 (0.41) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285608 | 0.92 | ADRB2 (0.49) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285140 | 0.91 | TRPV1 (0.40) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285470 | 0.91 | ADRB2 (0.40) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285264 | 0.91 | TRPV1 (0.43) | ADRB2TRPV1ADRA2AHTR2CAXL | |
| SCHEMBL1285259 | 0.89 | TRPV1 (0.42) | ADRB2TRPV1ADRA2AHTR2CAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | ADRB2 591/4885TRPV1 1/4885ADRA2A 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.