Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CPT2 | P23786 | 3/20 | 0.46 |
| ▸ | CPT1A | P50416 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.45 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAA50 | Q9GZZ1 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165849 | 1.00 | ROCK2 (0.49) | ROCK2CPT2CPT1AHSP90AA1HSP90AB1 | |
| SCHEMBL166241 | 0.89 | TRPV1 (0.42) | ROCK2CPT2CPT1AHSP90AA1HSP90AB1 | |
| SCHEMBL166240 | 0.89 | TRPV1 (0.42) | ROCK2CPT2CPT1AHSP90AA1HSP90AB1 | |
| SCHEMBL164419 | 0.89 | CPT2 (0.50) | ROCK2CPT2CPT1ACPT1BPOLB | |
| SCHEMBL166687 | 0.89 | CPT2 (0.50) | ROCK2CPT2CPT1ACPT1BPOLB | |
| SCHEMBL6466955 | 0.88 | BAZ2A (0.41) | ROCK2CPT2CPT1AHSP90AA1HSP90AB1 | |
| SCHEMBL3511003 | 0.88 | PARP14 (0.45) | CPT2CPT1APOLBTRPV1SMN1; SMN2 | |
| SCHEMBL3511008 | 0.88 | PARP14 (0.45) | CPT2CPT1APOLBTRPV1SMN1; SMN2 | |
| SCHEMBL10290101 | 0.88 | TRPV1 (0.48) | ROCK2CPT2CPT1ACPT1BPOLB | |
| SCHEMBL6464489 | 0.87 | POLB (0.39) | ROCK2CPT2CPT1AHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085571-B2 | Nonpeptide HIV-1 protease inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2015-07-21 | — | — | US | disclosed |
| US-9085571-B2 | Nonpeptide HIV-1 protease inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140315946-A1 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS | PURDUE RESEARCH FOUNDATION | 2014-10-23 | — | — | US | disclosed |
| US-20140315946-A1 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS | PURDUE RESEARCH FOUNDATION | 2014-10-23 | — | — | US | disclosed |
| US-8791135-B2 | Nonpeptide HIV-1 protease inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2014-07-29 | — | — | US | disclosed |
| US-8791135-B2 | Nonpeptide HIV-1 protease inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2014-07-29 | — | — | US | disclosed |
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| US-20130102593-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | PURDUE RESEARCH FOUNDATION | 2013-04-25 | — | — | US | disclosed |
| US-20130059840-A1 | SULFONAMIDO PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20120295894-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | BILCER GEOFFREY M (US) | 2012-11-22 | — | — | US | disclosed |
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
| EP-2411000-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2349244-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20110178123-A1 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178123-A1 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2011-07-21 | — | — | US | disclosed |
| US-20100286170-A1 | (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING | COMENTIS, INC | 2010-11-11 | — | — | US | disclosed |
| WO-2010110817-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010042892-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010002994-A1 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178123-A1 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS | DNPEP, PRSS1, SERPINB1 | ROCK2 3079/4885CPT2 4684/4885CPT1A 3469/4885 |
| US-20130059840-A1 | SULFONAMIDO PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | BACE1, BACE2, GSAP | ROCK2 4043/4885CPT2 4034/4885CPT1A 4546/4885 |
| US-20140315946-A1 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS | DNPEP, PRSS1, SERPINB1 | ROCK2 3090/4885CPT2 4668/4885CPT1A 3391/4885 |
| US-20120295894-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | BACE1, BACE2, APP | ROCK2 3071/4885CPT2 3164/4885CPT1A 3801/4885 |
| US-20120053200-A1 | BACE 2 INHIBITORS | BACE2, BACE1, PSEN2 | ROCK2 1674/4885CPT2 624/4885CPT1A 743/4885 |
| US-20100286170-A1 | (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING | BACE1, BACE2, PSEN1 | ROCK2 2452/4885CPT2 1089/4885CPT1A 2956/4885 |
| US-20130102593-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | BACE1, BACE2, APP | ROCK2 3071/4885CPT2 3164/4885CPT1A 3801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.