Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.50 |
| ▸ | MTOR | P42345 | 4/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644300 | 0.88 | TLR7 (0.57) | TLR7EGLN1TP53 | |
| SCHEMBL10272097 | 0.85 | SIRT2 (0.52) | PIK3CAPIK3R1MTORNPSR1ALOX15 | |
| SCHEMBL1643365 | 0.82 | KDM4E (0.53) | TLR7NPSR1TSHRHSD17B10ALDH1A1 | |
| SCHEMBL1644313 | 0.81 | HSD17B10 (0.62) | NPSR1CYP1A2ALOX15CYP2C19CYP2D6 | |
| SCHEMBL1644115 | 0.81 | ABCG2 (0.50) | TLR7NPSR1TSHRUSP2HSD17B10 | |
| SCHEMBL4303881 | 0.80 | TLR7 (0.61) | TLR7EGLN1HSD17B10 | |
| SCHEMBL1644154 | 0.79 | HDAC6 (0.46) | TLR7NPSR1CYP2C19ALDH1A1LMNA | |
| SCHEMBL1643369 | 0.79 | NTSR1 (0.53) | CYP1A2CYP2C19ALDH1A1TP53LMNA | |
| SCHEMBL1688393 | 0.76 | TLR7 (0.54) | TLR7NPSR1ALDH1A1LMNA | |
| SCHEMBL1645135 | 0.76 | MAPT (0.58) | NPSR1CYP1A2ALOX15CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | PIK3CA 1258/4885PIK3R1 3500/4885MTOR 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.