Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164426 | 0.90 | L3MBTL1 (0.55) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL6651573 | 0.88 | SMN1; SMN2 (0.49) | RAB9AALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL166870 | 0.84 | ALDH1A1 (0.56) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13534520 | 0.81 | HPGD (0.63) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL27680048 | 0.81 | HPGD (0.64) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL5321616 | 0.79 | HPGD (0.69) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL27737857 | 0.78 | HPGD (0.62) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL29451525 | 0.78 | NPC1 (0.60) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL740129 | 0.75 | HPGD (0.66) | HPGDRAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL166266 | 0.75 | RAB9A (0.54) | RAB9AHTTPOLBSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |