Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.47 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL21293916 | 1.00 | HSP90AA1 (0.47) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| Bromide SCHEMBL574336 | 1.00 | HSP90AA1 (0.47) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| SCHEMBL5304009 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5301214 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5817318 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5295433 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5295972 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5813633 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5298450 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5302619 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150045266-A1 | IONIC LIQUID AS LUBRICATING OIL BASE STOCKS, COBASE STOCKS AND MULTIFUNCTIONAL FUNCTIONAL FLUIDS | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045266-A1 | IONIC LIQUID AS LUBRICATING OIL BASE STOCKS, COBASE STOCKS AND MULTIFUNCTIONAL FUNCTIONAL FLUIDS | F12, F8, CEL | CHRM2 2534/4885CHRM4 3377/4885CHRM5 2372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.