Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.47 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL16445313 | 1.00 | HSP90AA1 (0.47) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| Bromide SCHEMBL574336 | 1.00 | HSP90AA1 (0.47) | HSP90AA1RAD52EGFRLMNAPLA2G1B | |
| SCHEMBL5304009 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5301214 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5817318 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5295433 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5295972 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5813633 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5298450 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE | |
| SCHEMBL5302619 | 0.99 | ABCB11 (0.46) | CHRM2ADRA2AADORA3CHRM1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043636-B2 | Method for producing triarylorganoborates | COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) | 2024-07-23 | — | — | US | disclosed |
| US-20240002409-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2024-01-04 | — | — | US | disclosed |
| US-11760765-B2 | Method for producing triarylorganoborates | COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) | 2023-09-19 | — | — | US | disclosed |
| US-20220002321-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2022-01-06 | — | — | US | disclosed |
| US-11078218-B2 | Process for the production of triaryl organoborates | COVESTRO DEUTSCHLAND AG (DE) | 2021-08-03 | — | — | US | disclosed |
| US-20190276479-A1 | PROCESS FOR THE PRODUCTION OF TRIARYL ORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2019-09-12 | — | — | US | disclosed |
| US-20190263838-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | COVESTRO DEUTSCHLAND AG (DE) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240002409-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | KMO, COASY, CYP3A4 | CHRM2 2050/4885CHRM4 1051/4885CHRM5 1994/4885 |
| US-11078218-B2 | Process for the production of triaryl organoborates | OR10J3, CYP4F3, CYP4B1 | CHRM2 95/4885CHRM4 51/4885CHRM5 652/4885 |
| US-12043636-B2 | Method for producing triarylorganoborates | KMO, COASY, CYP3A4 | CHRM2 2050/4885CHRM4 1051/4885CHRM5 1994/4885 |
| US-20190263838-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | CYP3A4, CYP3A43, CYP4B1 | CHRM2 1830/4885CHRM4 916/4885CHRM5 1809/4885 |
| US-20220002321-A1 | METHOD FOR PRODUCING TRIARYLORGANOBORATES | CYP3A4, CYP3A43, CYP4B1 | CHRM2 1830/4885CHRM4 916/4885CHRM5 1809/4885 |
| US-11760765-B2 | Method for producing triarylorganoborates | CYP3A4, CYP3A43, CYP4B1 | CHRM2 1830/4885CHRM4 916/4885CHRM5 1809/4885 |
| US-20190276479-A1 | PROCESS FOR THE PRODUCTION OF TRIARYL ORGANOBORATES | CYP1B1, CYP3A4, CYP4B1 | CHRM2 2058/4885CHRM4 701/4885CHRM5 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.