Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15351802 | 1.00 | PCSK9 (0.55) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL4449195 | 1.00 | PCSK9 (0.55) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL2653923 | 0.98 | PCSK9 (0.56) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL1128562 | 0.93 | PCSK9 (0.58) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| Phosphine SCHEMBL28357175 | 0.91 | PCSK9 (0.56) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL1275435 | 0.85 | PCSK9 (0.47) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL9226569 | 0.83 | PCSK9 (0.47) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL11711998 | 0.81 | PCSK9 (0.48) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL30545060 | 0.81 | PCSK9 (0.48) | PCSK9NR1I2CHRM2ADRA2AOPRK1 | |
| SCHEMBL30545064 | 0.81 | PCSK9 (0.48) | PCSK9NR1I2CHRM2ADRA2AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790423-B2 | Cyanated naphthalenebenzimidazole compounds | BASF SE (DE) | 2017-10-17 | — | — | US | disclosed |
| US-20160177177-A1 | CYANATED NAPHTHALENEBENZIMIDAZOLE COMPOUNDS | BASF SE (DE) | 2016-06-23 | — | — | US | disclosed |
| EP-3030628-A1 | CYANATED NAPHTHALENEBENZIMIDAZOLE COMPOUNDS | BASF SE (DE) | 2016-06-15 | — | — | EP | disclosed |
| WO-2015019270-A1 | CYANATED NAPHTHALENEBENZIMIDAZOLE COMPOUNDS | BASF SE (DE) | 2015-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160177177-A1 | CYANATED NAPHTHALENEBENZIMIDAZOLE COMPOUNDS | RB1, RARB, RARA | PCSK9 4057/4885NR1I2 117/4885CHRM2 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.