Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258217 | 0.89 | PSMB5 (0.58) | PSMB5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL987675 | 0.89 | PSMB5 (0.58) | PSMB5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL987963 | 0.89 | FAAH (0.64) | PSMB5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL11793269 | 0.89 | FAAH (0.64) | PSMB5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL265066 | 0.89 | FAAH (0.64) | PSMB5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16473192 | 0.87 | ALDH1A1 (0.60) | PSMB5ALDH1A1POLBACE | |
| SCHEMBL20468445 | 0.87 | ALDH1A1 (0.60) | PSMB5ALDH1A1POLBACE | |
| SCHEMBL16770417 | 0.85 | ALDH1A1 (0.55) | PSMB5ALDH1A1CTSGCMA1ACE | |
| SCHEMBL987191 | 0.85 | PSMB5 (0.64) | PSMB5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9487603 | 0.85 | POLB (0.67) | PSMB5ALDH1A1POLBHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952056-B2 | Methods for inhibiting drug degradation | SEQUOIA PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |