Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 11/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 11/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11836292 | 0.86 | SIGMAR1 (0.47) | SIGMAR1HSD17B1HSD17B2LMNANR1I2 | |
| SCHEMBL12164030 | 0.79 | LMNA (0.65) | SIGMAR1HSD17B1HSD17B2LMNANR1I2 | |
| SCHEMBL7641359 | 0.78 | HTR3E (0.66) | SIGMAR1HSD17B1HSD17B2LMNANR1I2 | |
| SCHEMBL6724109 | 0.76 | SIGMAR1 (0.52) | SIGMAR1LMNANR1I2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7411770 | 0.75 | SIGMAR1 (0.51) | SIGMAR1LMNANR1I2CYP1A2CYP3A4 | |
| SCHEMBL8204758 | 0.74 | SIGMAR1 (0.43) | SIGMAR1HSD17B1HSD17B2LMNANR1I2 | |
| SCHEMBL6720809 | 0.74 | SIGMAR1 (0.44) | SIGMAR1MAPT | |
| SCHEMBL6716723 | 0.73 | HDAC4 (0.43) | SIGMAR1CYP3A4MAPTCYP2C9HTR3E | |
| SCHEMBL6720760 | 0.73 | SIGMAR1 (0.43) | SIGMAR1HSD17B1HSD17B2LMNANR1I2 | |
| SCHEMBL11257031 | 0.72 | SCN4A (0.37) | SIGMAR1LMNACYP1A2MAPTHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015021092-A1 | POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO | ARROWHEAD RESEARCH CORPORATION (US) | 2015-02-12 | — | — | WO | disclosed |