Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL165702 | 0.91 | NR4A2 (0.47) | MAPK1NR4A2KEAP1ALDH1A1CYP2C19 | |
| Alpha-Ketoglutaric Acid SCHEMBL10389244 | 0.76 | MAPK1 (0.58) | MAPK1SLC13A3EGLN1OR51E2NR4A2 | |
| Acetone SCHEMBL28779633 | 0.73 | SMN1; SMN2 (0.37) | MAPK1ALDH1A1GAASMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL165681 | 0.72 | HCAR2 (0.43) | EGLN1ALDH1A1CYP2C19LMNAHDAC3 | |
| Alpha-Ketoglutaric Acid SCHEMBL29265285 | 0.72 | MAPK1 (0.58) | MAPK1SLC13A3EGLN1OR51E2NR4A2 | |
| Maleic Acid SCHEMBL29935550 | 0.72 | HCAR2 (0.43) | EGLN1ALDH1A1CYP2C19LMNAHDAC3 | |
| SCHEMBL164600 | 0.72 | PARP1 (0.42) | GAALMNATSHRMAPT | |
| Citric Acid SCHEMBL165526 | 0.71 | ALDH1A1 (0.50) | ALDH1A1CYP2C19CYP1A2LMNAHIF1A | |
| Alpha-Ketoglutaric Acid SCHEMBL27546478 | 0.71 | AKR1B1 (0.68) | MAPK1SLC13A3EGLN1OR51E2NR4A2 | |
| Trifluoroacetic Acid SCHEMBL507291 | 0.71 | CES1 (0.42) | MAPK1CYP1A2HDAC6CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |