Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.67 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.67 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.67 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.58 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29484401 | 1.00 | TXNRD1 (0.67) | TXNRD1TXNRD3TXNRD2GSTP1GSTM2 | |
| SCHEMBL4003277 | 0.86 | LMNA (0.68) | GSTP1GSTM2MAPTNPSR1GAA | |
| SCHEMBL2028311 | 0.85 | SLC6A2 (0.68) | GSTP1GSTM2MAPTGAALMNA | |
| SCHEMBL3174865 | 0.85 | GSTP1 (0.57) | TXNRD1TXNRD3TXNRD2GSTP1GSTM2 | |
| SCHEMBL17080274 | 0.85 | LMNA (0.63) | GSTP1GSTM2MAPTGAALMNA | |
| SCHEMBL1645181 | 0.85 | SLC6A4 (0.75) | GSTP1GSTM2MAPTGAALMNA | |
| SCHEMBL4001367 | 0.85 | GSTP1 (0.57) | TXNRD1TXNRD3TXNRD2GSTP1GSTM2 | |
| SCHEMBL1645800 | 0.85 | MAPT (0.60) | TXNRD1TXNRD3TXNRD2GSTP1GSTM2 | |
| SCHEMBL4636875 | 0.85 | PDE7A (0.66) | GSTP1GSTM2MAPTLMNAKDM4E | |
| SCHEMBL13240473 | 0.85 | LMNA (0.53) | TXNRD1TXNRD3TXNRD2GSTP1GSTM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111763187-B | Coumarin-based hydrogen sulfide fluorescent probe and preparation method and application thereof | 湖南科技大学 | 2022-09-30 | — | — | CN | claimed |
| CN-110903325-B | Cyclometalated iridium complex probe and preparation method and application thereof | 湖南科技大学 | 2022-05-13 | — | — | CN | claimed |
| CN-109485627-B | Coumarin derivative, synthesis method thereof and application of coumarin derivative in detection of hydrogen sulfide | 山西大学 | 2022-03-18 | — | — | CN | claimed |
| CN-111777572-A | Benzothiazole-based hydrogen sulfide fluorescent probe and preparation method and application thereof | 湖南科技大学 | 2020-10-16 | — | — | CN | claimed |
| CN-111763187-A | Coumarin-based hydrogen sulfide fluorescent probe and preparation method and application thereof | 湖南科技大学 | 2020-10-13 | — | — | CN | claimed |
| CN-110903325-A | Ring metal iridium complex probe and preparation method and application thereof | 湖南科技大学 | 2020-03-24 | — | — | CN | claimed |
| EP-3490552-B1 | SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1 | UNIV SOUTHERN CALIFORNIA (US) | 2022-11-23 | — | — | EP | disclosed |
| CN-111763187-B | Coumarin-based hydrogen sulfide fluorescent probe and preparation method and application thereof | 湖南科技大学 | 2022-09-30 | — | — | CN | disclosed |
| CN-110903325-B | Cyclometalated iridium complex probe and preparation method and application thereof | 湖南科技大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-109485627-B | Coumarin derivative, synthesis method thereof and application of coumarin derivative in detection of hydrogen sulfide | 山西大学 | 2022-03-18 | — | — | CN | disclosed |
| US-10918647-B2 | Selective bromodomain inhibition of fungal Bdf1 | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2021-02-16 | — | — | US | disclosed |
| CN-111777572-A | Benzothiazole-based hydrogen sulfide fluorescent probe and preparation method and application thereof | 湖南科技大学 | 2020-10-16 | — | — | CN | disclosed |
| CN-111763187-A | Coumarin-based hydrogen sulfide fluorescent probe and preparation method and application thereof | 湖南科技大学 | 2020-10-13 | — | — | CN | disclosed |
| CN-110903325-A | Ring metal iridium complex probe and preparation method and application thereof | 湖南科技大学 | 2020-03-24 | — | — | CN | disclosed |
| US-20190240232-A1 | SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1 | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2019-08-08 | — | — | US | disclosed |
| EP-3490552-A1 | SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1 | University of Southern California (US) | 2019-06-05 | — | — | EP | disclosed |
| CN-109485627-A | A kind of coumarin derivative and its synthetic method and the application in detection hydrogen sulfide | 山西大学 | 2019-03-19 | — | — | CN | disclosed |
| WO-2018022802-A1 | SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1 | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2018-02-01 | — | — | WO | disclosed |
| US-20110097274-A1 | Carbon-11 and fluorine-18 labeled radioligands for positron emission tomography (PET) imaging for the brain serotonin transporters | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10918647-B2 | Selective bromodomain inhibition of fungal Bdf1 | BRPF3, BRD3, BRD1 | TXNRD1 3647/4885TXNRD3 3034/4885TXNRD2 3978/4885 |
| US-20110097274-A1 | Carbon-11 and fluorine-18 labeled radioligands for positron emission tomography (PET) imaging for the brain serotonin transporters | SLC6A4, SLC18A2, SLC6A2 | TXNRD1 2389/4885TXNRD3 2940/4885TXNRD2 3023/4885 |
| US-20190240232-A1 | SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1 | BRPF3, BRD3, BRD1 | TXNRD1 3647/4885TXNRD3 3034/4885TXNRD2 3978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.