Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16454833 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBPKMALDH1A1KDM4E | |
| SCHEMBL16454675 | 0.80 | HSD11B1 (0.39) | HSD11B1NR1I2MAPK13 | |
| SCHEMBL16454821 | 0.79 | HSD11B1 (0.44) | HSD11B1HPGDNR1I2 | |
| SCHEMBL16454896 | 0.77 | ALDH1A1 (0.51) | HSD11B1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16454895 | 0.76 | HSD11B1 (0.48) | HSD11B1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16454893 | 0.75 | NPSR1 (0.55) | HSD11B1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16454904 | 0.75 | RAB9A (0.50) | HSD11B1NPC1RAB9ANR1I2ALDH1A1 | |
| SCHEMBL16454891 | 0.73 | NPSR1 (0.53) | HSD11B1NPC1RAB9APOLBNR1I2 | |
| SCHEMBL16454882 | 0.73 | SMN1; SMN2 (0.54) | HPGDSMN1; SMN2NR1I2ALDH1A1KDM4E | |
| SCHEMBL16454892 | 0.72 | NPSR1 (0.52) | HSD11B1SMN1; SMN2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015020565-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[4,3-A]PYRIDINES EXHIBITING ANTAGONIST PROPERTIES TO ADENOSINE A2A RECEPTORS, AND USE THEREOF | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НЬЮВАК" (ООО "НЬЮВАК") (RU) | 2015-02-12 | — | — | WO | disclosed |