Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MTTP | P55157 | 6/20 | 0.42 |
| ▸ | UGCG | Q16739 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455120 | 0.90 | UGCG (0.49) | UGCGCYP3A4KDM1AEPHX2 | |
| SCHEMBL16455198 | 0.89 | KDM1A (0.48) | UGCGKDM1A | |
| SCHEMBL16455068 | 0.84 | KDM1A (0.46) | MEN1HPGDKMT2AKDM1A | |
| SCHEMBL16455201 | 0.81 | MEN1 (0.50) | MEN1HPGDTSHRKMT2AMTTP | |
| SCHEMBL16455175 | 0.79 | UGCG (0.50) | UGCGKDM1A | |
| SCHEMBL20781661 | 0.79 | KDM1A (0.44) | MEN1KMT2AKDM1AEPHX2 | |
| SCHEMBL16455032 | 0.79 | MEN1 (0.50) | MEN1HPGDTSHRKMT2AMTTP | |
| SCHEMBL16455122 | 0.76 | UGCG (0.51) | KMT2AUGCGCYP3A4 | |
| SCHEMBL18848618 | 0.76 | KMT2A (0.51) | KMT2AUGCGCYP3A4KDM1A | |
| SCHEMBL18848470 | 0.76 | HPGD (0.47) | MEN1HPGDTSHRKMT2AMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |
| WO-2015021128-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES INC. (US) | 2015-02-12 | — | — | WO | disclosed |