Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | MTTP | P55157 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16447419 | 0.90 | MEN1 (0.51) | MEN1HPGDTSHRKMT2AKDM1A | |
| SCHEMBL16447416 | 0.90 | MEN1 (0.51) | MEN1HPGDTSHRKMT2AKDM1A | |
| SCHEMBL16455179 | 0.89 | KDM1A (0.48) | KDM1ACA12CA1CA9CA2 | |
| SCHEMBL16455166 | 0.88 | KDM1A (0.59) | KDM1ACPB2 | |
| SCHEMBL16448250 | 0.85 | MEN1 (0.49) | MEN1HPGDTSHRKMT2AKDM1A | |
| SCHEMBL16448249 | 0.85 | MEN1 (0.49) | MEN1HPGDTSHRKMT2AKDM1A | |
| SCHEMBL18848693 | 0.85 | KDM1A (0.61) | KDM1ACA12CA1CA9CA2 | |
| SCHEMBL18848471 | 0.85 | CTSB (0.57) | HPGDKDM1ACPB2HPGDS | |
| SCHEMBL18848704 | 0.84 | KDM1A (0.54) | KDM1A | |
| SCHEMBL18848748 | 0.84 | CTSB (0.58) | HPGDKDM1ACPB2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |
| WO-2015021128-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES INC. (US) | 2015-02-12 | — | — | WO | disclosed |