Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 14/20 | 0.59 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18043477 | 0.89 | KDM1A (0.60) | KDM1AALOX5TGM2 | |
| SCHEMBL16447169 | 0.89 | KDM1A (0.60) | KDM1AALOX5TGM2 | |
| SCHEMBL16455201 | 0.88 | MEN1 (0.50) | KDM1ACPB2 | |
| SCHEMBL16455182 | 0.88 | KDM1A (0.53) | KDM1ATGM2 | |
| SCHEMBL18848746 | 0.88 | KDM1A (0.58) | KDM1A | |
| SCHEMBL16455202 | 0.87 | KDM1A (0.65) | KDM1A | |
| SCHEMBL18848471 | 0.87 | CTSB (0.57) | KDM1ACPB2 | |
| SCHEMBL18848757 | 0.86 | KDM1A (0.66) | KDM1ATGM2 | |
| SCHEMBL18848748 | 0.86 | CTSB (0.58) | KDM1ACPB2 | |
| SCHEMBL22856674 | 0.85 | KDM1A (0.59) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |
| WO-2015021128-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES INC. (US) | 2015-02-12 | — | — | WO | disclosed |