Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.58 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 5/20 | 0.52 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18848471 | 0.99 | CTSB (0.57) | CTSBHPGDSKDM1ACPB2P2RY12 | |
| SCHEMBL16455072 | 0.90 | KDM1A (0.60) | CTSBHPGDSKDM1AP2RY12 | |
| SCHEMBL18848468 | 0.90 | CTSB (0.55) | CTSBHPGDSKDM1AP2RY12HPGD | |
| SCHEMBL18848749 | 0.89 | KDM1A (0.61) | CTSBHPGDSKDM1A | |
| SCHEMBL20913184 | 0.88 | KDM1A (0.52) | CTSBKDM1AP2RY12HPGDMAPK1 | |
| SCHEMBL20913183 | 0.88 | KDM1A (0.52) | CTSBKDM1AP2RY12HPGDMAPK1 | |
| SCHEMBL16455183 | 0.86 | KDM1A (0.64) | CTSBHPGDSKDM1AP2RY12 | |
| SCHEMBL16455166 | 0.86 | KDM1A (0.59) | KDM1ACPB2 | |
| SCHEMBL18023290 | 0.85 | KDM1A (0.61) | CTSBHPGDSKDM1A | |
| SCHEMBL18016053 | 0.84 | KDM1A (0.55) | HPGDSKDM1AP2RY12HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |