Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457520 | 0.89 | TP53 (0.42) | TRPV3CNR1MAPTHTTNPC1 | |
| SCHEMBL16457214 | 0.88 | TRPV3 (0.44) | TRPV3MAPTHTTNPC1ALDH1A1 | |
| SCHEMBL16457550 | 0.88 | MAPT (0.43) | TRPV3MAPTHTTNPC1ALDH1A1 | |
| SCHEMBL16457324 | 0.87 | GPR119 (0.45) | TRPV3CNR1MAPTALDH1A1THRB | |
| SCHEMBL16457034 | 0.86 | TRPV3 (0.45) | TRPV3CNR1MAPTHTTALDH1A1 | |
| SCHEMBL9927822 | 0.86 | KDM4E (0.44) | TRPV3CNR1MAPTALDH1A1MAPK1 | |
| SCHEMBL2063726 | 0.86 | THRB (0.44) | TRPV3CNR1MAPTHTTTHRB | |
| SCHEMBL16457111 | 0.85 | MAPT (0.39) | TRPV3CNR1MAPTHTTNPC1 | |
| SCHEMBL16457110 | 0.85 | MAPT (0.39) | TRPV3CNR1MAPTHTTNPC1 | |
| SCHEMBL16457172 | 0.85 | MAPT (0.39) | TRPV3CNR1MAPTHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |