Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16964268 | 0.82 | MPO (0.39) | MPOPTGS2PTGS1KMT2AMEN1 | |
| SCHEMBL26125006 | 0.81 | MPO (0.32) | MPO | |
| SCHEMBL31319669 | 0.80 | TLR8 (0.40) | — | |
| SCHEMBL31319756 | 0.79 | P2RX7 (0.31) | — | |
| SCHEMBL31319713 | 0.79 | PKM (0.40) | PTGS2 | |
| SCHEMBL15652891 | 0.79 | LRRK2 (0.38) | MPOLRRK2 | |
| SCHEMBL24469847 | 0.78 | CYP1A2 (0.40) | MPOPTGS2PTGS1KMT2AMEN1 | |
| SCHEMBL31319708 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL26124377 | 0.78 | LRRK2 (0.38) | MPOLRRK2 | |
| SCHEMBL17076735 | 0.78 | LRRK2 (0.39) | MPOKMT2ACYP1A2LRRK2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475644-B1 | HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2014-01-08 | — | — | EP | claimed |