Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 8/20 | 0.33 |
| ▸ | CBX7 | O95931 | 1/20 | 0.32 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966197 | 0.83 | PRKAG1 (0.45) | PRKAG1PRKAA1PRKAB1CMA1EGLN1 | |
| SCHEMBL16457730 | 0.79 | PRKAG1 (0.62) | PRKAG1PRKAA1PRKAB1GAAMEN1 | |
| SCHEMBL1965288 | 0.73 | PRKAG1 (0.51) | PRKAG1PRKAA1PRKAB1GAAL3MBTL1 | |
| SCHEMBL1975246 | 0.73 | PRKAG1 (0.51) | PRKAG1PRKAA1PRKAB1GAAL3MBTL1 | |
| SCHEMBL1968170 | 0.71 | CMA1 (0.37) | PRKAG1PRKAA1PRKAB1CMA1 | |
| SCHEMBL31518544 | 0.71 | L3MBTL1 (0.49) | GAAL3MBTL1ALDH1A1TDP1CMA1 | |
| SCHEMBL13270283 | 0.70 | PRKAG1 (0.42) | PRKAG1PRKAA1PRKAB1GAAALDH1A1 | |
| SCHEMBL1982462 | 0.70 | PRKAG1 (0.42) | PRKAG1PRKAA1PRKAB1GAAALDH1A1 | |
| SCHEMBL28686162 | 0.69 | CMA1 (0.46) | PRKAG1PRKAA1PRKAB1CMA1NOTUM | |
| SCHEMBL1974678 | 0.68 | PRKAG1 (0.65) | PRKAG1PRKAA1PRKAB1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509946-B1 | SPIRO INDOLE-CYCLOPROPANE INDOLINONES USEFUL AS AMPK MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-04-16 | — | — | EP | claimed |