Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 17/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | LDLR | P01130 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15648081 | 0.88 | RORC (0.52) | RORC | |
| SCHEMBL16461369 | 0.86 | RORC (0.50) | RORCHPGDSLDLRPCSK9IDO1 | |
| SCHEMBL16461142 | 0.85 | RORC (0.53) | RORC | |
| SCHEMBL16461259 | 0.85 | RORC (0.53) | RORC | |
| SCHEMBL16460135 | 0.85 | RORC (0.35) | RORCHPGDSLDLRPCSK9 | |
| SCHEMBL16459639 | 0.85 | RORC (0.55) | RORC | |
| SCHEMBL16462345 | 0.85 | RORC (0.44) | RORC | |
| SCHEMBL16462063 | 0.84 | RORC (0.51) | RORC | |
| SCHEMBL17666777 | 0.83 | RORC (0.43) | RORC | |
| SCHEMBL16458991 | 0.83 | RORC (0.45) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909193-B1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-19 | — | — | EP | disclosed |
| US-9309222-B2 | Phenyl linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-12 | — | — | US | disclosed |
| US-20140107097-A1 | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107097-A1 | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | RORC 1/4885HPGDS 1601/4885LDLR 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.