SCHEMBL16461663

SCHEMBL16461663

COC(=O)/C(=C\N(C)C)C(=O)c1cc(Br)c(OC)cc1OC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.40
HPGD P15428 1/20 0.40
CYP11B1 P15538 2/20 0.40
CYP11B2 P19099 1/20 0.40
ABCB1 P08183 1/20 0.40
CYP3A4 P08684 1/20 0.40
PAX8 Q06710 1/20 0.39
LCK P06239 1/20 0.36
FYN P06241 1/20 0.36
TNFRSF1A P19438 2/20 0.35
ALDH1A1 P00352 4/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
CYP1A2 P05177 1/20 0.34
HTR1A P08908 1/20 0.34
ADRA2A P08913 1/20 0.34
CYP2D6 P10635 1/20 0.34
DRD1 P21728 1/20 0.34
ACHE P22303 1/20 0.34
PTGS1 P23219 1/20 0.34
DRD3 P35462 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16461664 1.00 MAPT (0.40) MAPTHPGDCYP11B1CYP11B2ABCB1
SCHEMBL1300338 0.88 LMNA (0.41) MAPTHPGDCYP11B1CYP11B2ABCB1
SCHEMBL1300340 0.88 LMNA (0.41) MAPTHPGDCYP11B1CYP11B2ABCB1
SCHEMBL2181651 0.88 CYP11B1 (0.41) HPGDCYP11B1CYP11B2ABCB1CYP3A4
SCHEMBL2181660 0.88 CYP11B1 (0.41) HPGDCYP11B1CYP11B2ABCB1CYP3A4
SCHEMBL16461661 0.84 CYP3A4 (0.40) MAPTHPGDCYP11B1CYP11B2CYP3A4
SCHEMBL16461662 0.84 CYP3A4 (0.40) MAPTHPGDCYP11B1CYP11B2CYP3A4
SCHEMBL16465757 0.83 ABCB1 (0.36) MAPTHPGDABCB1CYP3A4PAX8
SCHEMBL16465755 0.83 ABCB1 (0.36) MAPTHPGDABCB1CYP3A4PAX8
SCHEMBL4409246 0.78 LMNA (0.39) MAPTHPGDCYP11B1CYP11B2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2906529-B9 A NEW PRODUCTION METHOD AND NEW INTERMEDIATES OF SYNTHESIS OF ELVITEGRAVIR ZENTIVA KS (CZ) 2017-03-15 EP disclosed
EP-2906529-B1 A NEW PRODUCTION METHOD AND NEW INTERMEDIATES OF SYNTHESIS OF ELVITEGRAVIR ZENTIVA KS (CZ) 2016-11-23 EP disclosed
EP-2906529-A1 A NEW PRODUCTION METHOD AND NEW INTERMEDIATES OF SYNTHESIS OF ELVITEGRAVIR Zentiva K.S. (CZ) 2015-08-19 EP disclosed
WO-2014056464-A1 A NEW PRODUCTION METHOD AND NEW INTERMEDIATES OF SYNTHESIS OF ELVITEGRAVIR ZENTIVA, K.S. (CZ) 2014-04-17 WO disclosed