Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16464321 | 0.81 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL10726904 | 0.80 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3KCNH2TRPM8 | |
| SCHEMBL13434170 | 0.78 | POLQ (0.54) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL13434159 | 0.76 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3KCNH2TRPM8 | |
| SCHEMBL4469871 | 0.74 | TSHR (0.50) | SLC6A4SLC6A2SLC6A3TP53LMNA | |
| SCHEMBL4560310 | 0.72 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL16487401 | 0.72 | SMN1; SMN2 (0.58) | SLC6A4SLC6A2SLC6A3CHRM4CYP3A4 | |
| SCHEMBL13911241 | 0.72 | SLC6A4 (0.56) | SLC6A4SLC6A2KCNH2TRPM8 | |
| SCHEMBL10724404 | 0.71 | TRPM8 (0.55) | SLC6A4SLC6A2SLC6A3TRPM8TP53 | |
| SCHEMBL16465413 | 0.71 | KCNA5 (0.40) | SLC6A4SLC6A2SLC6A3CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200054630-A1 | BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION | MINDIMMUNE THERAPEUTICS, INC. | 2020-02-20 | — | — | US | disclosed |
| US-10238654-B2 | Benzamides-containing compounds and their use in the treatment of epilepsy | MINDIMMUNE THERAPEUTICS, INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20170202836-A1 | Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy | H. LUNDBECK A/S (DK) | 2017-07-20 | — | — | US | disclosed |
| US-9649308-B2 | Benzamide-containing compounds and their use in the treatment of pain | H. LUNDBECK A/S (DK) | 2017-05-16 | — | — | US | disclosed |
| US-20150283134-A1 | Benzamides | MINDIMMUNE THERAPEUTICS, INC. | 2015-10-08 | — | — | US | disclosed |
| EP-2906546-A1 | BENZAMIDES | H. Lundbeck A/S (DK) | 2015-08-19 | — | — | EP | disclosed |
| US-9102591-B2 | Benzamides | H. LUNDBECK A/S (DK) | 2015-08-11 | — | — | US | disclosed |
| WO-2014057078-A1 | BENZAMIDES | H. LUNDBECK A/S (DK) | 2014-04-17 | — | — | WO | disclosed |
| US-20140107340-A1 | Benzamides | H. LUNDBECK A/S (DK) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200054630-A1 | BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION | P2RX5, P2RX7, P2RX2 | SLC6A4 81/4885SLC6A2 227/4885SLC6A3 349/4885 |
| US-20140107340-A1 | Benzamides | P2RX7, TRPV1, P2RX5 | SLC6A4 432/4885SLC6A2 1000/4885SLC6A3 954/4885 |
| US-10238654-B2 | Benzamides-containing compounds and their use in the treatment of epilepsy | P2RX5, P2RX7, P2RX6 | SLC6A4 554/4885SLC6A2 784/4885SLC6A3 1126/4885 |
| US-20170202836-A1 | Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy | P2RX5, P2RX7, P2RX6 | SLC6A4 554/4885SLC6A2 784/4885SLC6A3 1126/4885 |
| US-20150283134-A1 | Benzamides | P2RX7, TRPV1, P2RX5 | SLC6A4 432/4885SLC6A2 1000/4885SLC6A3 954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.