Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19029329 | 0.80 | HPGDS (0.38) | HTTAPPHPGDSKDM4EALDH1A1 | |
| SCHEMBL27619683 | 0.71 | HPGDS (0.35) | HTTAPPHPGDSHRH3DYRK1A | |
| SCHEMBL842815 | 0.70 | HPGDS (0.42) | HTTAPPHPGDSKDM4EALDH1A1 | |
| SCHEMBL27724202 | 0.69 | HPGDS (0.41) | HTTAPPHPGDSKDM4EALDH1A1 | |
| SCHEMBL1894034 | 0.68 | EGFR (0.53) | HTTAPPHPGDSKDM4EALDH1A1 | |
| SCHEMBL19029379 | 0.67 | HDAC6 (0.57) | APPHPGDSL3MBTL1 | |
| SCHEMBL13835653 | 0.67 | HTT (0.43) | HTTAPPHPGDSKDM4EALDH1A1 | |
| SCHEMBL5251617 | 0.66 | HPGDS (0.45) | HTTAPPHPGDSKDM4EALDH1A1 | |
| Aniline SCHEMBL28107592 | 0.65 | ALDH1A1 (0.49) | HTTHPGDSKDM4EALDH1A1GAA | |
| SCHEMBL5765965 | 0.65 | HTT (0.64) | HTTHPGDSKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014059185-A1 | AMINO - DIHYDROTHIAZINE AND AMINO - DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2014-04-17 | — | — | WO | disclosed |