Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634631 | 0.82 | PLAU (0.44) | PLAUPTPN1LMNAMCL1HCAR2 | |
| SCHEMBL30143410 | 0.80 | PLAU (0.48) | PLAUMKNK1MKNK2SIRT6MAP2 | |
| SCHEMBL2760820 | 0.80 | PLAU (0.48) | PLAUMKNK1MKNK2SIRT6MAP2 | |
| SCHEMBL3924687 | 0.78 | MKNK1 (0.42) | PLAUMKNK1MKNK2SIRT6MAP2 | |
| SCHEMBL22854468 | 0.77 | MAP2K1 (0.37) | HCAR2MAP2K1PARP1SPR | |
| SCHEMBL6302474 | 0.77 | NNMT (0.42) | PLAUMAP2NNMT | |
| SCHEMBL7910786 | 0.77 | BACE1 (0.39) | PLAUMKNK1MKNK2SIRT6MAP2 | |
| SCHEMBL31006673 | 0.77 | PTPN1 (0.49) | PLAUPTPN1LMNAL3MBTL1 | |
| SCHEMBL16634805 | 0.77 | PTPN1 (0.49) | PLAUPTPN1LMNAL3MBTL1 | |
| SCHEMBL22610076 | 0.77 | ALDH1A1 (0.40) | PLAUPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014059185-A1 | AMINO - DIHYDROTHIAZINE AND AMINO - DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2014-04-17 | — | — | WO | disclosed |