Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31006673 | 1.00 | PTPN1 (0.49) | PTPN1NPSR1ALDH1A1L3MBTL1PLAU | |
| SCHEMBL29796660 | 0.82 | S1PR4 (0.46) | NPSR1ALDH1A1L3MBTL1S1PR4OPRK1 | |
| SCHEMBL1420843 | 0.82 | S1PR4 (0.46) | NPSR1ALDH1A1L3MBTL1S1PR4OPRK1 | |
| SCHEMBL6057160 | 0.82 | NPSR1 (0.43) | NPSR1OPRK1KMT2AMAPK1TSHR | |
| SCHEMBL31306162 | 0.82 | GABRA1 (0.39) | PTPN1PLAUGABRA1GABRG2GABRB3 | |
| SCHEMBL17978199 | 0.81 | MAPK1 (0.51) | NPSR1ALDH1A1L3MBTL1KMT2AKDM4E | |
| SCHEMBL26910332 | 0.81 | NPSR1 (0.42) | PTPN1NPSR1ALDH1A1KMT2AKDM4E | |
| SCHEMBL1915284 | 0.81 | ATM (0.47) | NPSR1ALDH1A1L3MBTL1OPRK1KDM4E | |
| SCHEMBL10314919 | 0.81 | NPSR1 (0.42) | NPSR1L3MBTL1KDM4EPOLBMAPK1 | |
| SCHEMBL31255330 | 0.79 | ALDH1A1 (0.44) | NPSR1ALDH1A1L3MBTL1S1PR4OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260022114-A1 | N-(5-SUBSTITUTED-[(1,3,4-THIADIAZOLYL) OR (1,3-THIAZOLYL)](SUBSTITUTED)CARBOXAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING THE AMIDE COMPOUNDS AND OF THEIR USE | GILEAD SCIENCES, INC. | 2026-01-22 | — | — | US | disclosed |
| US-12441726-B2 | Compounds and uses thereof | FOGHORN THERAPEUTICS, INC. (US) | 2025-10-14 | — | — | US | disclosed |
| EP-4594316-A1 | N-(5-SUBSTITUTED-[(1,3,4-THIADIAZOLYL) OR (1,3-THIAZOLYL)](SUBSTITUTED)CARBOXAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING THE AMIDE COMPOUNDS AND OF THEIR USE | Repare Therapeutics Inc. (CA) | 2025-08-06 | — | — | EP | disclosed |
| EP-4419525-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LTD (GB) | 2025-07-23 | — | — | EP | disclosed |
| US-20250230165-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2025-07-17 | — | — | US | disclosed |
| US-20250026748-A1 | N-(5-SUBSTITUTED-[(1,3,4-THIADIAZOLYL) OR (THIAZOLYL)])(SUBSTITUTED)CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR INHIBITING HUMAN POLYMERASE THETA | REPARE THERAPEUTICS INC. (CA) | 2025-01-23 | — | — | US | disclosed |
| CN-113874363-B | Protein tyrosine phosphatase inhibitors | ARRAY生物制药公司 | 2024-11-12 | — | — | CN | disclosed |
| WO-2024218499-A1 | HETEROCYCLIC INHIBITORS OF DNA POLYMERASE THETA FOR THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2024-10-24 | — | — | WO | disclosed |
| WO-2024197401-A1 | 1,3,4-THIADIAZOL-2-YL CARBOXAMIDE AND 1,3-THIAZOL-2-YL CARBOXAMIDE COMPOUNDS AND USES THEREOF AS INHIBITORS OF HUMAN POLYMERASE THETA | REPARE THERAPEUTICS INC. (CA) | 2024-10-03 | — | — | WO | disclosed |
| EP-4419525-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| US-20200317665-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-10-08 | — | — | US | disclosed |
| US-10239863-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180179180-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179180-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20160257668-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257668-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257668-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| EP-3054944-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054087-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |
| WO-2015054087-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260022114-A1 | N-(5-SUBSTITUTED-[(1,3,4-THIADIAZOLYL) OR (1,3-THIAZOLYL)](SUBSTITUTED)CARBOXAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING THE AMIDE COMPOUNDS AND OF THEIR USE | POLK, POLQ, POLB | PTPN1 2879/4885NPSR1 4413/4885ALDH1A1 3422/4885 |
| US-20250026748-A1 | N-(5-SUBSTITUTED-[(1,3,4-THIADIAZOLYL) OR (THIAZOLYL)])(SUBSTITUTED)CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR INHIBITING HUMAN POLYMERASE THETA | POLA1, POLL, POLD1 | PTPN1 1331/4885NPSR1 1516/4885ALDH1A1 789/4885 |
| US-20180179180-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | PTPN1 3604/4885NPSR1 3358/4885ALDH1A1 3635/4885 |
| US-20200317665-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS | PPM1A, PPM1F, PPP5C | PTPN1 5/4885NPSR1 2977/4885ALDH1A1 1829/4885 |
| US-20160257668-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | PTPN1 3604/4885NPSR1 3358/4885ALDH1A1 3635/4885 |
| US-12441726-B2 | Compounds and uses thereof | VHL, CLN6, TFEB | PTPN1 4436/4885NPSR1 4599/4885ALDH1A1 2571/4885 |
| US-10239863-B2 | Factor XIa inhibitors | F11, SERPINC1, TFPI | PTPN1 3604/4885NPSR1 3358/4885ALDH1A1 3635/4885 |
| US-20250230165-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | NQO1, VHL, SDHA | PTPN1 3404/4885NPSR1 3492/4885ALDH1A1 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.