Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 17/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25439487 | 0.79 | BCL6 (0.41) | PTPN11MAPTPOLB | |
| Hydrochloric Acid SCHEMBL31148435 | 0.79 | BCL6 (0.40) | PTPN11MAPTPOLB | |
| SCHEMBL14746664 | 0.77 | PTPN11 (0.53) | PTPN11POLB | |
| SCHEMBL31485489 | 0.74 | MAPT (0.45) | PTPN11MAPTPOLB | |
| SCHEMBL25419558 | 0.74 | MAPT (0.45) | PTPN11MAPTPOLB | |
| SCHEMBL5800464 | 0.72 | LCK (0.45) | — | |
| SCHEMBL16671809 | 0.72 | MEN1 (0.52) | POLB | |
| SCHEMBL4126532 | 0.72 | HTR7 (0.48) | PTPN11MAPT | |
| SCHEMBL31485521 | 0.72 | MAT2A (0.47) | PTPN11MAPTPOLB | |
| Hydrochloric Acid SCHEMBL25213549 | 0.71 | MAT2A (0.47) | PTPN11MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903970-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014058921-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | WO | disclosed |