Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1349390 | 0.92 | CHRNA3 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL1349388 | 0.92 | CHRNA3 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL1348694 | 0.89 | NPC1 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL1348691 | 0.89 | NPC1 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL1645371 | 0.83 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL1349661 | 0.81 | CHRNA3 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1349658 | 0.81 | CHRNA3 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1349655 | 0.81 | CHRNA3 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1349660 | 0.81 | CHRNA3 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1350466 | 0.79 | CHRNA3 (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4663627-B2 | — | — | 2011-04-06 | — | — | JP | claimed |
| JP-2006519868-A | — | — | 2006-08-31 | — | — | JP | claimed |
| EP-1601670-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | Targacept Inc. (US) | 2005-12-07 | — | — | EP | claimed |
| WO-2004078752-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT INC. (US) | 2004-09-16 | — | — | WO | claimed |