SCHEMBL1645371

SCHEMBL1645371

C(=C/C1CNC1)\c1cncc(OCC2CC2)c1.CN1CC(/C=C/c2ccc(Cl)nc2)C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 7/20 0.39
CHRNA3 P32297 6/20 0.39
CHRNB4 P30926 5/20 0.39
CHRNB1 P11230 4/20 0.39
CHRNB3 Q05901 4/20 0.39
AKT1 P31749 4/20 0.38
CHRNA4 P43681 4/20 0.35
CHUK O15111 1/20 0.32
DYRK3 O43781 1/20 0.32
ROCK2 O75116 1/20 0.32
MAP4K4 O95819 1/20 0.32
PIM1 P11309 1/20 0.32
PRKACA P17612 1/20 0.32
RPS6KB1 P23443 1/20 0.32
CLK2 P49760 1/20 0.32
PRKX P51817 1/20 0.32
PRKG2 Q13237 1/20 0.32
ROCK1 Q13464 1/20 0.32
DYRK1A Q13627 1/20 0.32
PRKG1 Q13976 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6102061 0.87 CHRNB1 (0.36) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL6102057 0.87 CHRNB1 (0.36) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL4754478 0.86 CHRNA3 (0.37) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL1347835 0.85 CHRNB2 (0.47) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL1347834 0.85 CHRNB2 (0.47) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL1347036 0.83 AKT1 (0.48) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL1347039 0.83 AKT1 (0.48) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL1646633 0.83 CHRNB2 (0.39) CHRNB2CHRNA3CHRNB4CHRNA4CHRNA7
SCHEMBL2214142 0.81 AKT1 (0.42) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3
SCHEMBL2214139 0.81 AKT1 (0.42) CHRNB2CHRNA3CHRNB4CHRNB1CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4663627-B2 2011-04-06 JP claimed
JP-2006519868-A 2006-08-31 JP claimed
EP-1601670-A1 ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF Targacept Inc. (US) 2005-12-07 EP claimed
WO-2004078752-A1 ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF TARGACEPT INC. (US) 2004-09-16 WO claimed
EP-1601670-A1 ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF Targacept Inc. (US) 2005-12-07 EP disclosed
WO-2004078752-A1 ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF TARGACEPT INC. (US) 2004-09-16 WO disclosed