Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 2/20 | 0.74 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.74 |
| ▸ | DHFR | P00374 | 2/20 | 0.61 |
| ▸ | MTR | Q99707 | 1/20 | 0.60 |
| ▸ | GART | P22102 | 6/20 | 0.57 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.57 |
| ▸ | ATIC | P31939 | 4/20 | 0.56 |
| ▸ | TYMS | P04818 | 1/20 | 0.54 |
| ▸ | FPGS | Q05932 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Folitixorin SCHEMBL4108452 | 1.00 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Arfolitixorin SCHEMBL29616436 | 1.00 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Arfolitixorin SCHEMBL186747 | 1.00 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL50782 | 1.00 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL258730 | 1.00 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL3180668 | 1.00 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL4537420 | 0.99 | MTHFD2 (0.73) | MTHFD2MTHFD1DHFRMTRGART | |
| Arfolitixorin SCHEMBL30694324 | 0.99 | MTHFD2 (0.73) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL29556725 | 0.98 | MTHFD2 (0.72) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL9430909 | 0.97 | MTHFD2 (0.70) | MTHFD2MTHFD1DHFRMTRGART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113603691-B | Preparation process of L-5-methyl tetrahydrofolic acid calcium | 连云港冠昕医药科技有限公司 | 2022-08-26 | — | — | CN | claimed |
| US-20240400574-A1 | NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID | Merck & Cie (CH) | 2024-12-05 | — | — | US | disclosed |
| US-12103930-B2 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2024-10-01 | — | — | US | disclosed |
| CN-113603691-B | Preparation process of L-5-methyl tetrahydrofolic acid calcium | 连云港冠昕医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |
| US-11337978-B2 | Stable lyophilisates comprising 5,10-methylene-(6R)-tetrahydrofolic acid | MERCK PATENT GMBH (DE) | 2022-05-24 | — | — | US | disclosed |
| US-20220143027-A1 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2022-05-12 | — | — | US | disclosed |
| US-11306094-B2 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2022-04-19 | — | — | US | disclosed |
| US-20220024940-A1 | STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID | Merck & Cie (CH) | 2022-01-27 | — | — | US | disclosed |
| EP-3668516-B1 | STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID AND A DICARBOXYLIC ACID | MERCK PATENT GMBH (DE) | 2021-09-22 | — | — | EP | disclosed |
| EP-3287460-B1 | HEMISULFATE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID | Merck & Cie (CH) | 2021-02-24 | — | — | EP | disclosed |
| US-10570134-B2 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2020-02-25 | — | — | US | disclosed |
| US-20190270745-A1 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2019-09-05 | — | — | US | disclosed |
| US-10336758-B2 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2019-07-02 | — | — | US | disclosed |
| US-20190106431-A1 | NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID | Merck & Cie (CH) | 2019-04-11 | — | — | US | disclosed |
| US-10059710-B2 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2018-08-28 | — | — | US | disclosed |
| US-20180134711-A1 | New stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2018-05-17 | — | — | US | disclosed |
| EP-3287460-A1 | HEMISULFATE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID | Merck & Cie (CH) | 2018-02-28 | — | — | EP | disclosed |
| US-20170233394-A1 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2017-08-17 | — | — | US | disclosed |
| US-20160185787-A1 | NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID | Merck & Cie (CH) | 2016-06-30 | — | — | US | disclosed |
| EP-2837631-A1 | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2015-02-18 | — | — | EP | disclosed |