Arfolitixorin

Arfolitixorin

SCHEMBL186747

Nc1nc2c(c(=O)[nH]1)N1CN(c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)C[C@H]1CN2

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MTHFD2 P13995 2/20 0.74
MTHFD1 P11586 2/20 0.74
DHFR P00374 2/20 0.61
MTR Q99707 1/20 0.60
GART P22102 6/20 0.57
SOST Q9BQB4 1/20 0.57
ATIC P31939 4/20 0.56
TYMS P04818 1/20 0.54
FPGS Q05932 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Folitixorin SCHEMBL4108452 1.00 MTHFD2 (0.74) MTHFD2MTHFD1DHFRMTRGART
Arfolitixorin SCHEMBL29616436 1.00 MTHFD2 (0.74) MTHFD2MTHFD1DHFRMTRGART
Folitixorin SCHEMBL16467076 1.00 MTHFD2 (0.74) MTHFD2MTHFD1DHFRMTRGART
Folitixorin SCHEMBL50782 1.00 MTHFD2 (0.74) MTHFD2MTHFD1DHFRMTRGART
Folitixorin SCHEMBL258730 1.00 MTHFD2 (0.74) MTHFD2MTHFD1DHFRMTRGART
Folitixorin SCHEMBL3180668 1.00 MTHFD2 (0.74) MTHFD2MTHFD1DHFRMTRGART
Folitixorin SCHEMBL4537420 0.99 MTHFD2 (0.73) MTHFD2MTHFD1DHFRMTRGART
Arfolitixorin SCHEMBL30694324 0.99 MTHFD2 (0.73) MTHFD2MTHFD1DHFRMTRGART
Folitixorin SCHEMBL29556725 0.98 MTHFD2 (0.72) MTHFD2MTHFD1DHFRMTRGART
Folitixorin SCHEMBL9430909 0.97 MTHFD2 (0.70) MTHFD2MTHFD1DHFRMTRGART

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 515 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260063623-A1 METHODS OF ASSESSING METABOLIC FLUX UNIV MICHIGAN REGENTS (US) 2026-03-05 US claimed
US-20260048054-A1 ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF L E A F HOLDINGS GROUP LLC (US) 2026-02-19 US claimed
US-12527796-B2 [6R]-MTHF—an efficient folate alternative in 5-fluorouracil based chemotherapy ISOFOL MEDICAL AB (SE) 2026-01-20 US claimed
US-12336994-B2 Alpha polyglutamated tetrahydrofolates and uses thereof L.E.A.F. HOLDINGS GROUP LLC (US) 2025-06-24 US claimed
EP-4536184-A1 CONCENTRATED SOLUTIONS COMPRISING SODIUM 5,10-METHYLENE-(6R)- TETRAHYDROFOLATE Merck Patent GmbH (DE) 2025-04-16 EP claimed
EP-4536188-A1 STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID Merck Patent GmbH (DE) 2025-04-16 EP claimed
EP-4534088-A1 ARFOLITIXORIN FOR USE IN VITAMIN B6-ENHANCED, 5-FLUOROURACIL-BASED CHEMOTHERAPY OF CARCINOMAS Isofol Medical AB (SE) 2025-04-09 EP claimed
US-20250064736-A1 GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF L.E.A.F. HOLDINGS GROUP LLC 2025-02-27 US claimed
US-20240415837-A1 PHARMACOLOGIC MODULATION OF 5-FLUOROURACIL BY FOLINIC ACID AND VITAMIN B6 FOR THE TREATMENT OF PATIENTS WITH CARCINOMA MACHOVER DAVID (FR) 2024-12-19 US claimed
US-20240350495-A1 [6R]-MTHF IN B6 ENHANCED 5-FU BASED CHEMOTHERAPY OF CARCINOMA ISOFOL MEDICAL AB (SE) 2024-10-24 US claimed
EP-4114399-A1 FOLATE PREPARATIONS FOR THE TREATMENT OF OCULAR DISEASES Aprofol AG (CH) 2023-01-11 EP claimed
EP-3735267-B1 ADMINSITRATION OF MULTIPLE BOLUSES OF [6R] MTHF IN A 5-FLUOROURACIL-BASED CHEMOTHERAPY ISOFOL MEDICAL AB (SE) 2022-09-14 EP claimed
US-20210346381-A1 ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF L.E.A.F. HOLDINGS GROUP LLC 2021-11-11 US claimed
US-20210128469-A1 GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF L.E.A.F HOLDINGS GROUP LLC 2021-05-06 US claimed
CN-111971047-A Gamma polyglutamated tetrahydrofolic acid and application thereof L.E.A.F.控股集团公司 2020-11-20 CN claimed
CN-111936146-A Alpha polyglutamated tetrahydrofolic acid and application thereof L.E.A.F.控股集团公司 2020-11-13 CN claimed
CN-106103698-B Chemically defined cell culture medium additives 汉阳大学校产学协力团 2020-08-21 CN claimed
US-20170009199-A1 CHEMICALLY DEFINED CELL CULTURE MEDIA ADDITIVE IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (KR) 2017-01-12 US claimed
CN-106103698-A The additive of the cell culture medium that chemical composition determines 汉阳大学校产学协力团 2016-11-09 CN claimed
EP-1724356-B1 Method for producing ß-hydroxy amino acid and enzyme used therefore AJINOMOTO KK (JP) 2009-09-09 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12336994-B2 Alpha polyglutamated tetrahydrofolates and uses thereof DHFR, FPGS, MTHFD1 MTHFD2 6/4885MTHFD1 3/4885DHFR 1/4885
US-20210128469-A1 GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF FPGS, DHFR, MTHFD1 MTHFD2 6/4885MTHFD1 3/4885DHFR 2/4885
US-20260063623-A1 METHODS OF ASSESSING METABOLIC FLUX PC, SLC2A1, SLC2A4 MTHFD2 733/4885MTHFD1 750/4885DHFR 2642/4885
US-20260048054-A1 ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF FOLR2, FOLR1, FPGS MTHFD2 7/4885MTHFD1 4/4885DHFR 5/4885
US-20250064736-A1 GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF FPGS, DHFR, MTHFD1 MTHFD2 6/4885MTHFD1 3/4885DHFR 2/4885
US-12527796-B2 [6R]-MTHF—an efficient folate alternative in 5-fluorouracil based chemotherapy MTHFD1, MTHFD2, FOLR1 MTHFD2 2/4885MTHFD1 1/4885DHFR 5/4885
US-20210346381-A1 ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF DHFR, FPGS, MTHFD1 MTHFD2 6/4885MTHFD1 3/4885DHFR 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.