Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 2/20 | 0.72 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.72 |
| ▸ | DHFR | P00374 | 2/20 | 0.60 |
| ▸ | MTR | Q99707 | 1/20 | 0.59 |
| ▸ | GART | P22102 | 6/20 | 0.56 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.56 |
| ▸ | ATIC | P31939 | 4/20 | 0.55 |
| ▸ | TYMS | P04818 | 1/20 | 0.53 |
| ▸ | FPGS | Q05932 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arfolitixorin SCHEMBL186747 | 0.98 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL3180668 | 0.98 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL16467076 | 0.98 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL50782 | 0.98 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL258730 | 0.98 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL4108452 | 0.98 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Arfolitixorin SCHEMBL29616436 | 0.98 | MTHFD2 (0.74) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL4537420 | 0.98 | MTHFD2 (0.73) | MTHFD2MTHFD1DHFRMTRGART | |
| Arfolitixorin SCHEMBL30694324 | 0.98 | MTHFD2 (0.73) | MTHFD2MTHFD1DHFRMTRGART | |
| Folitixorin SCHEMBL9430909 | 0.95 | MTHFD2 (0.70) | MTHFD2MTHFD1DHFRMTRGART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12103930-B2 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2024-10-01 | — | — | US | disclosed |
| US-20220143027-A1 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2022-05-12 | — | — | US | disclosed |