Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 2/20 | 0.45 |
| ▸ | GHSR | Q92847 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15542733 | 1.00 | NPC1 (0.47) | NPC1HPGDRAB9AGPR183GHSR | |
| SCHEMBL15543144 | 0.91 | NPC1 (0.44) | NPC1HPGDRAB9AGPR183GHSR | |
| SCHEMBL15543143 | 0.91 | NPC1 (0.44) | NPC1HPGDRAB9AGPR183GHSR | |
| SCHEMBL16468502 | 0.87 | GHSR (0.52) | GHSRALDH1A1TP53USP2POLB | |
| SCHEMBL16468504 | 0.87 | GHSR (0.52) | GHSRALDH1A1TP53USP2POLB | |
| SCHEMBL15543486 | 0.86 | SMN1; SMN2 (0.48) | NPC1RAB9AGHSRALDH1A1USP2 | |
| SCHEMBL15543487 | 0.86 | SMN1; SMN2 (0.48) | NPC1RAB9AGHSRALDH1A1USP2 | |
| SCHEMBL15543280 | 0.84 | MDH1 (0.47) | GHSRALDH1A1USP2CYP3A4FKBP1A | |
| SCHEMBL16468189 | 0.84 | MDH1 (0.47) | GHSRALDH1A1USP2CYP3A4FKBP1A | |
| SCHEMBL16468226 | 0.80 | RAB9A (0.47) | NPC1HPGDRAB9AGPR183GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051144-A1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER DISEASES | CADILA HEALTHCARE LTD (IN) | 2015-02-19 | — | — | US | claimed |
| US-20150051144-A1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER DISEASES | CADILA HEALTHCARE LTD (IN) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051144-A1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER DISEASES | PCSK9, HMGCR, CETP | NPC1 14/4885HPGD 847/4885RAB9A 3260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.