Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165657 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBL3MBTL1KCNQ2TSHR | |
| SCHEMBL28057844 | 0.82 | MAPT (0.56) | SMN1; SMN2LMNAL3MBTL1TSHRKMT2A | |
| SCHEMBL1646819 | 0.80 | APOBEC3A (0.57) | SMN1; SMN2LMNAPOLBL3MBTL1KCNQ2 | |
| SCHEMBL1644755 | 0.79 | POLB (0.54) | SMN1; SMN2POLBL3MBTL1KCNQ2KMT2A | |
| SCHEMBL1645825 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2LMNAPOLBL3MBTL1KCNQ2 | |
| SCHEMBL16993891 | 0.76 | GAA (0.56) | SMN1; SMN2LMNAPOLBL3MBTL1TSHR | |
| SCHEMBL1643882 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2POLBL3MBTL1KCNQ2TSHR | |
| SCHEMBL13419737 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBTSHRKMT2ANPSR1 | |
| SCHEMBL1459682 | 0.73 | MAPT (0.57) | SMN1; SMN2LMNAPOLBTSHRKMT2A | |
| SCHEMBL2275286 | 0.72 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPOLBL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4665239-B2 | — | — | 2011-04-06 | — | — | JP | claimed |
| JP-2002512230-A | — | — | 2002-04-23 | — | — | JP | claimed |
| EP-1071668-A1 | 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS | Du Pont Pharmaceuticals Company (US) | 2001-01-31 | — | — | EP | claimed |
| WO-1999054308-A1 | 5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-10-28 | — | — | WO | claimed |