Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16993891 | 0.84 | GAA (0.56) | SMN1; SMN2GAAALDH1A1MAPTBCHE | |
| SCHEMBL1459682 | 0.83 | MAPT (0.57) | SMN1; SMN2GAAALDH1A1MAPTTSHR | |
| SCHEMBL2226706 | 0.82 | GAA (0.55) | SMN1; SMN2GAAALDH1A1MAPTBCHE | |
| SCHEMBL7832611 | 0.81 | GAA (0.54) | SMN1; SMN2GAAALDH1A1MAPTBCHE | |
| SCHEMBL7243129 | 0.81 | KMT2A (0.53) | SMN1; SMN2GAAALDH1A1MAPTLMNA | |
| SCHEMBL30070503 | 0.81 | MEN1 (0.57) | SMN1; SMN2GAAENPP2ALDH1A1MAPT | |
| SCHEMBL8879964 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2GAAALDH1A1MAPTBCHE | |
| SCHEMBL28057844 | 0.80 | MAPT (0.56) | SMN1; SMN2GAAALDH1A1MAPTTSHR | |
| SCHEMBL28826843 | 0.80 | MAPT (0.57) | SMN1; SMN2GAAENPP2ALDH1A1MAPT | |
| SCHEMBL27955987 | 0.79 | MAPT (0.53) | SMN1; SMN2GAAALDH1A1MAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523945-A1 | 1 - (2 - PHENOXYMETHYLPHENYL) PIPERAZINE COMPOUNDS AS SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | Theravance, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011085291-A1 | 1 - (2 - PHENOXYMETHYLPHENYL) PIPERAZINE COMPOUNDS AS SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | THERAVANCE, INC. (US) | 2011-07-14 | — | — | WO | disclosed |