Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695941 | 0.84 | POLB (0.57) | GAASMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL4958829 | 0.84 | POLB (0.57) | GAASMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL11058044 | 0.81 | KMT2A (0.41) | SMN1; SMN2POLBKMT2AMEN1NPC1 | |
| Fluoride SCHEMBL11791995 | 0.79 | ABCC1 (0.40) | SMN1; SMN2POLBKMT2AMEN1NPC1 | |
| SCHEMBL22469129 | 0.76 | KCNMA1 (0.38) | GAASMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL29177406 | 0.76 | HTT (0.38) | SMN1; SMN2POLBKMT2AMEN1NPC1 | |
| SCHEMBL6960305 | 0.75 | GAA (0.56) | GAASMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL27828990 | 0.75 | GAA (0.46) | GAASMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL6397287 | 0.74 | KCNMA1 (0.69) | GAASMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL27877164 | 0.74 | CXCR2 (0.67) | GAASMN1; SMN2POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314240-B2 | Sulfonamide compounds or salts thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-20 | — | — | US | disclosed |
| EP-2305641-A1 | SULFONAMIDE COMPOUND OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2011-04-06 | — | — | EP | disclosed |