Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | APAF1 | O14727 | 1/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.52 |
| ▸ | CDC25A | P30304 | 2/20 | 0.52 |
| ▸ | CDC25B | P30305 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16473010 | 0.83 | ALDH1A1 (0.68) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL6367155 | 0.82 | TOP1 (0.69) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL11524597 | 0.80 | TOP1 (0.66) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL16473004 | 0.80 | ALDH1A1 (0.62) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL16473005 | 0.80 | ALDH1A1 (0.62) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL12827331 | 0.79 | TOP1 (1.00) | TOP1MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL17594035 | 0.78 | ALDH1A1 (0.61) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL15994240 | 0.78 | MAPT (0.61) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL9627716 | 0.76 | ALDH1A1 (1.00) | TOP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL30003269 | 0.76 | ALDH1A1 (1.00) | TOP1MAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180049997-A1 | CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2018-02-22 | — | — | US | disclosed |
| US-20180049997-A1 | CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2018-02-22 | — | — | US | disclosed |
| US-9890106-B2 | Anti-cancer lead molecule | KING ABDULLAH UNIVERSITY OF SCIENCE & TECHNOLOGY (SA) | 2018-02-13 | — | — | US | disclosed |
| US-9890106-B2 | Anti-cancer lead molecule | KING ABDULLAH UNIVERSITY OF SCIENCE & TECHNOLOGY (SA) | 2018-02-13 | — | — | US | disclosed |
| WO-2016135633-A1 | CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER | KING ABDULLAH UNIVERSITY OF SCIENCE & TECHNOLOGY (SA) | 2016-09-01 | — | — | WO | disclosed |
| US-20140107196-A1 | ANTI-CANCER LEAD MOLECULE | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2014-04-17 | — | — | US | disclosed |
| US-20140107196-A1 | ANTI-CANCER LEAD MOLECULE | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107196-A1 | ANTI-CANCER LEAD MOLECULE | ACAT2, BRCA1, ALPG | TOP1 2029/4885MAPT 1522/4885ALDH1A1 127/4885 |
| US-20180049997-A1 | CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITION IN THE TREATMENT OF CANCER | CETP, LCAT, MTTP | TOP1 2193/4885MAPT 2961/4885ALDH1A1 3140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.