Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27579381 | 0.82 | LTA4H (0.59) | MAPK14LTA4HL3MBTL1NR3C1PGR | |
| SCHEMBL693792 | 0.82 | NR4A2 (0.62) | MAPK14CHEK2NR3C1PGRAR | |
| SCHEMBL11071994 | 0.81 | MAOB (0.63) | MAPK14LTA4HCHEK2CYP1A2CYP2C9 | |
| SCHEMBL9546526 | 0.81 | L3MBTL1 (0.55) | MAPK14LTA4HL3MBTL1NR3C1PGR | |
| SCHEMBL23244709 | 0.80 | L3MBTL1 (0.51) | MAPK14LTA4HL3MBTL1NR3C1PGR | |
| SCHEMBL9798371 | 0.79 | LTA4H (0.54) | LTA4HL3MBTL1NR3C1PGRAR | |
| SCHEMBL694268 | 0.78 | MAPT (0.61) | MAPK14CHEK2L3MBTL1TLR8TLR7 | |
| SCHEMBL11069694 | 0.78 | MAPK14 (0.52) | MAPK14LTA4HCHEK2L3MBTL1TLR8 | |
| SCHEMBL13809396 | 0.78 | LTA4H (0.52) | MAPK14LTA4HL3MBTL1NR3C1PGR | |
| SCHEMBL9589615 | 0.78 | LTA4H (0.53) | MAPK14LTA4HNR3C1PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |