Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14233661 | 0.87 | ADORA1 (0.49) | TLR9KDM4ERETALKRAB9A | |
| SCHEMBL16474222 | 0.86 | TLR9 (0.50) | TLR9ACHEMAPTSMN1; SMN2KDM4E | |
| SCHEMBL16474226 | 0.78 | TLR9 (0.76) | TLR9 | |
| SCHEMBL14233909 | 0.76 | ACHE (0.53) | TLR9ACHEMAPTSMN1; SMN2KDM4E | |
| SCHEMBL16474215 | 0.75 | ADORA3 (0.47) | NPC1RAB9A | |
| SCHEMBL14233654 | 0.73 | ADORA1 (0.49) | TLR9KDM4EAURKAFLT3RPS6KA3 | |
| SCHEMBL28084733 | 0.73 | TLR9 (0.47) | TLR9MAPTKDM4EGAAGFER | |
| SCHEMBL14104418 | 0.72 | ADORA3 (0.37) | SMN1; SMN2MAPK9NPC1RAB9A | |
| SCHEMBL8511903 | 0.72 | KMT2A (0.49) | MAPTSMN1; SMN2KDM4EGAARAB9A | |
| SCHEMBL5162476 | 0.71 | GAA (0.61) | TLR9ACHEMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353115-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-9353115-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| EP-2713737-B1 | NOVEL IMMUNE SYSTEM MODULATORS | JANUS BIOTHERAPEUTICS INC (US) | 2016-04-20 | — | — | EP | disclosed |
| US-20140107115-A1 | NOVEL IMMUNE SYSTEM MODULATORS | JANUS BIOTHERAPEUTICS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107115-A1 | NOVEL IMMUNE SYSTEM MODULATORS | JANUS BIOTHERAPEUTICS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107115-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | TLR9 19/4885ACHE 3450/4885MAPT 2510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.